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KMID : 1007520150240020725
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Food Science and Biotechnology
2015 Volume.24 No. 2 p.725 ~ p.733
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Diallyl Trisulfide Ameliorates Arsenic Induced Dyslipidemia in Rats
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Selvaraj Miltonprabu
Naorem Chanu Sumedha
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Abstract
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The efficacy of diallyl trisulfide (DATS) against arsenic (As) induced dyslipidemia in the plasma and livers of rats was studied. Oral administration of As [5 mg/kg of body weight (BW)/day] for 4 weeks showed significant (p<0.05) increases in TC, LDL-C, VLDL-C, FFA, PL, and TG levels and the activity of HMG-CoA reductase in the plasma and liver, with significant (p<0.05) reductions in levels of HDL-C hepatic ubiquinones and activities of LCAT and LPL in the plasma and liver. Oral administration of DATS (80 mg/kg of BW) for 4 weeks in As intoxicated rats significantly (p<0.05) reduced plasma and liver TC, FFA, TGs, VLDL-C, and LDL-C levels, and the activity of HMG-CoA reductase, and significantly (p<0.05) increased the activities of LCAT and LPL and the levels of HDL-C and ubiquinone in the livers of rats. DATS protects against As-induced dyslipidemia in rats.
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KEYWORD
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diallyl trisulfide, arsenic, lipid, lipoprotein, ubiquinone
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